Iranian Journal of Health and Environment
سلامت و محیط زیست
ijhe
Medical Sciences
http://ijhe.tums.ac.ir
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2008-2029
2008-3718
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jalali
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2023
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بررسی رابطه غلظت ذرات معلق با غلظت آنزیم های کبدی بندناف نوزاد (مطالعه موردی: شهر اصفهان)
The relationship between particulate matter and neonate liver enzymes concentration (case study: Isfahan city)
هوا
Air
پژوهشي
Research
<div style="text-align: justify;"><span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:150%"><span style="direction:rtl"><span style="unicode-bidi:embed"><b><span lang="FA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" lotus="" style="font-family:">زمینه و هدف: </span></span></span></b><span lang="FA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" lotus="" style="font-family:">ذرات معلق از آلایندههای مهم هوا در مناطق شهری با تأثیرات شناخته نشده بر روی جنین هستند. لذا هدف مطالعه حاضر، تعیین اثر غلظت ذرات معلق با قطر آئرودینامیکی کوچکتر مساوی </span></span></span><span dir="LTR" style="line-height:150%"><span new="" roman="" style="font-family:" times=""> μm</span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" lotus="" style="font-family:">2/5</span></span></span> <span lang="FA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" lotus="" style="font-family:">در محل زندگی مادر، بر سطح آنزیم ­های کبدی خون بندناف نوزاد در شهر اصفهان است. </span></span></span></span></span></span></span></span><br>
<span style="text-justify:kashida"><span style="text-kashida:0%"><span style="line-height:150%"><span style="direction:rtl"><span style="unicode-bidi:embed"><b><span lang="FA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" lotus="" style="font-family:">روش بررسی: </span></span></span></b><span lang="FA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" lotus="" style="font-family:">سطح آنزیم­ های کبدی در خون بند ناف 200 نوزاد در سال­ های 1398 و 1399 در شهر اصفهان با استفاده از کیت­ های تشخیص کمی و به روش اسپکتروفتومتری محاسبه شد. غلظت </span></span></span><span dir="LTR" style="line-height:150%"><span new="" roman="" style="font-family:" times="">PM<sub>2.5</sub></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" lotus="" style="font-family:"> نیز با استفاده از داده­­ های ایستگاه ­های پایش، مدل­سازی و همبستگی آن با سطوح آنزیم­ های کبدی به تفکیک سه ماه بارداری و در شعاعهای</span></span></span><span dir="LTR" style="line-height:150%"><span new="" roman="" style="font-family:" times="">m </span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" lotus="" style="font-family:"> 500،</span></span></span><span dir="LTR" style="line-height:150%"><span new="" roman="" style="font-family:" times="">m </span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" lotus="" style="font-family:">1000 و</span></span></span><span dir="LTR" style="line-height:150%"><span new="" roman="" style="font-family:" times="">m</span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" lotus="" style="font-family:"> 2000 محاسبه شد. <span style="color:red"></span></span></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:150%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><b><span lang="FA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" lotus="" style="font-family:">یافته ­ها:</span></span></span></b><span lang="FA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" lotus="" style="font-family:"> متوسط سطح آسپارات آمینو ترانسفراز (</span></span></span><span dir="LTR" style="line-height:150%"><span new="" roman="" style="font-family:" times="">Aspartate Aminotransferase (AST)</span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" lotus="" style="font-family:">)</span></span></span> <span lang="FA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" lotus="" style="font-family:">برابر با 38/42، آلانین آمینوترانسفراز (</span></span></span><span dir="LTR" style="line-height:150%"><span new="" roman="" style="font-family:" times="">Alanine Aminotransferase (ALT)</span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" lotus="" style="font-family:">)</span></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" lotus="" style="font-family:"> برابر با </span></span></span><span dir="LTR" style="line-height:150%"><span new="" roman="" style="font-family:" times="">IU/L</span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" lotus="" style="font-family:"> 10/09، آلکالین فسفاتاژ (</span></span></span><span dir="LTR" style="line-height:150%"><span new="" roman="" style="font-family:" times="">Alkaline Phosphatase (ALP)</span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" lotus="" style="font-family:">) برابر با </span></span></span><span dir="LTR" style="line-height:150%"><span new="" roman="" style="font-family:" times=""> IU/L</span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" lotus="" style="font-family:"> 407 و گاما گلونامیل ترانسفراز (</span></span></span><span dir="LTR" style="line-height:150%"><span new="" roman="" style="font-family:" times="">Gamma-Glutamyl Transpeptidase (GGT)</span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" lotus="" style="font-family:">)</span></span></span> <span lang="FA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" lotus="" style="font-family:">برابر با </span></span></span><span dir="LTR" style="line-height:150%"><span new="" roman="" style="font-family:" times="">IU/L</span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" lotus="" style="font-family:"> 152 بدست آمد. فصول بهار و پاییز با غلظت ذرات 22/77 و </span></span></span><span dir="LTR" style="line-height:150%"><span new="" roman="" style="font-family:" times="">μg/m<sup>3</sup></span></span><span style="font-size:12.0pt"><span style="line-height:150%"><span b="" lotus="" style="font-family:"> 35/35 به ترتیب دارای حداقل و حداکثر غلظت ذرات معلق بودند. در کلیه آنزیم ­های مورد بررسی، غلظت آنزیم با سه ماهه سوم بارداری و کل دوران بارداری در شعاعهای </span></span></span><span dir="LTR" style="line-height:150%"><span new="" roman="" style="font-family:" times="">m</span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" lotus="" style="font-family:"> 2000</span></span></span> <span lang="FA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" lotus="" style="font-family:">دارای ضریب همبستگی متوسط بودند که این امر حکایت از تاثیر معنی­ دار غلظت­ های بالای </span></span></span> <span dir="LTR" style="line-height:150%"><span new="" roman="" style="font-family:" times="">PM<sub>2.5</sub></span></span><span lang="FA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" lotus="" style="font-family:">بر غلظت آنزیمهای کبد نوزادان به ­خصوص در اواخر دوران بارداری دارد.</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:150%"><span style="font-family:"B Lotus""></span></span></span></span></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:150%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><b><span lang="FA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" lotus="" style="font-family:">نتیجه­ گیری: </span></span></span></b><span lang="FA" style="font-size:12.0pt"><span style="line-height:150%"><span b="" lotus="" style="font-family:">نزدیکی به منابع تولید کننده ذرات معلق در شهرها، احتمال افزایش غلظت آنزیم ­های کبدی جنین را به­ خصوص در اواخر دوره بارداری افزایش می­ دهد.</span></span></span><span lang="AR-SA" style="font-size:12.0pt"><span style="line-height:150%"><span style="font-family:"B Lotus""></span></span></span></span></span></span></span></span><br>
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<div style="text-align: justify;"><span style="font-size:11pt"><span style="line-height:107%"><span calibri="" style="font-family:"><b><span new="" roman="" style="font-family:" times="">Background and Objective:</span></b><span new="" roman="" style="font-family:" times=""> Particulate matter is an important air pollutant in urban areas with unknown effects on the fetus.</span> <span new="" roman="" style="font-family:" times="">The present study investigated the effect of PM<sub>2.5</sub> concentration on the level of liver enzymes in the neonate born in Isfahan city, one of the most polluted cities in Iran was investigated</span><span dir="RTL" new="" roman="" style="font-family:" times="">.</span><span style="font-family:"Times New Roman","serif""></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:107%"><span calibri="" style="font-family:"><b><span new="" roman="" style="font-family:" times="">Materials and Methods: </span></b><span new="" roman="" style="font-family:" times="">This case study was conducted between March 2019 to September 2020 in Isfahan. Blood samples were collected from the umbilical cord of 200 newborns to measure the level of liver enzymes from their blood serum using quantitative diagnostic kits and the spectrophotometry method. Seasonal distribution of PM<sub>2.5</sub> concentrations was estimated using the data of monitoring stations; thus, modeled and used to measure their correlations with liver enzyme levels at trimester in buffers of 500, 1000, and 2000 meters. </span><span dir="RTL" style="font-family:"Times New Roman","serif"" lang="FA"></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:107%"><span calibri="" style="font-family:"><b><span new="" roman="" style="font-family:" times="">Results: </span></b><span new="" roman="" style="font-family:" times="">The mean levels of liver enzymes were 38.42 (AST), 10.09 (ALT), 407 (ALP), and 152 (GGT) IU/L. Spring and fall with PM<sub>2.5</sub> concentrations of 24.35 and 35.35 and μg/m<sup>3</sup> had the lowest and highest levels, respectively. Enzyme levels within the third trimester and the whole period of pregnancy in the 2000-m buffers had the highest correlation coefficient, which indicates the effect of high PM<sub>2.5</sub> concentrations on neonatal liver function, especially in late pregnancy.</span><span dir="RTL" style="font-family:"Times New Roman","serif"" lang="FA"></span></span></span></span><br>
<span style="font-size:11pt"><span style="line-height:107%"><span calibri="" style="font-family:"><b><span new="" roman="" style="font-family:" times="">Conclusion: </span></b><span new="" roman="" style="font-family:" times="">Proximity to particulate matter sources in cities will increase the likelihood of elevated neonatal liver enzymes during the fetal period which is higher and more effective in late pregnancy.</span><span dir="RTL" style="font-family:"Times New Roman","serif"" lang="FA"></span></span></span></span><br>
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خون بند ناف, آنزیم های کبدی, ذرات معلق
Umbilical cord blood, Liver enzymes, Particulate matter
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http://ijhe.tums.ac.ir/browse.php?a_code=A-10-1500-2&slc_lang=fa&sid=1
Zohreh
Nourouzi
زهره
نوروزی
zibarokh_2002@yahoo.com