Background and Objectives: In this experimental study, we used Analytical Hierarchy Process method to determine the best wastewater treatment process for dairy products factories. That is a multi-criteria decision making techniques and is based on expert knowledge. Materials and Methods: First, we formed the hierarchical structure and defined the main criteria and indicators. Then, we investigated the current situation of the treatment process through field observations and conducting influent-effluent analysis. Later, we converted the results obtained into quantitative indices. Then we weighted the main criteria, and their related sub criteria, depending on existing conditions we performed the experiments required and considered the experts ideas. Finally, Evaluation and prioritization of the options was conducted using Expert choice software. Then the sensitivity analysis was performed for main criteria and we evaluated the influence of the parameters weight change on the options. Results: In comparison with the main criteria, environmental criteria were more important followed by engineering criteria, economic and management criteria. Conclusions: Due to the influence of various parameters in choosing optimal wastewater treatment, Multi-criteria decision-making methods are necessary. Finally, “UASB + Aeration” was found to be the first priority followed by “Anaerobic filter + Aeration”, “Anaerobic lagoon + Aeration (2) + Sedimentation (2)”,” Anaerobic filter + Aeration (2) + Sedimentation (2)”. “Septic tank + Trickling filter + Aeration” system was found to be less preferable than other options.